Activated Folate 5 mg

• Contains 5 mg of Quatrefolic 5 MTHF, the active form of folate
• Many people can not effectively metabolize folic acid, the synthetic form of folate.  This form is very much preferable. 
• Be careful when starting any form of 5-MTHF, it can be very powerful if your body is not used to it.  If you have never taken it, start with a low dose (1 mg or less) and increase slowly, preferably while collaborating with a knowledgeable physician. 
• People who are very sensitive to folate may benefit from taking Magnesium, Molybdenum, B6, and Niacin before taking it.  

Activated Folate 5mg is the most biologically active form of folate, also known as folic acid. The Quatrefolic® form of 5-MTHF contained in Activated Folate is the most soluble, bioavailable, and stable form of folate. 5-MTHF is water soluble, and has been shown to be more effective than folate forms which bind to calcium¹. Studies show that 5-MTHF is more effective than traditional folic acid², which is a synthetic form a folate that does not normally exist in food, but is popular in cheap supplements and fortified grains. 5-MTHF is especially important for people with the low functioning genetic variant of the MTHFR gene, which impairs the body's ability to utilize dietary folate³. In these people, synthetic folic acid should be avoided. This product contains 5 mg of 5-MTHF and is certified allergen free (gluten, dairy, soy). If you have not taken 5-MTHF before, you should start with a lower dose. Excess MTHF can cause headache, nausea, agitation, and tremors. **

¹ Crossover Comparative Bioavailability Study of 5-Methyltetrahydrofolate Glucosamine Salt (GN10G) Compared to the Reference Metafolin® in Healthy Volunteers. IPAS-5MTHFA-583-09 final report. Desio, Italy: Gnosis S.p.A.; March 15, 2010: 1-33.

² Venn BJ, Green TJ, Moser R, et al. Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study. Am J Clin Nutr. 2003 Mar;77(3):658-62. PMID: 12600857.

³ Colson, N.J., Naug, H.L., Nikbakht, E., Zhang, P., McCormack, J. The impact of MTHFR 677 C/T genotypes on folate status markers: a meta-analysis of folic acid intervention studies. Eur J Nutr. 2017 Feb;56(1):247-60. PMID: 26497154.

** These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.