Estrogen Balance
- Supports optimal estrogen metabolism for improved breast and prostate health
- The addition of Calcium D-Glucarate further reduces estrogen sensitivity and is recommended for more estrogen dominant individuals.
Estrogen Balance is a targeted supplement that offers the benefits of the cruciferous vegetable metabolites Indole-3-carbinol (I3C) and diindolylmethane (DIM) to support proper estrogen metabolism. The combination of I3C and DIM offers an ideal blend of beneficial metabolites that work together to support estrogen balance for both men and women. Current data on I3C and DIM, suggests that these phytonutrients have strong potential for supporting breast, cervical, uterine and prostate health.1-4
Calcium D-Glucarate helps to bind and remove estrogen from the body, as well as reducing estrogen activity at the receptor sites, by way of a detoxification mechanism called glucuronidation. The human body uses glucuronidation to make a large variety of substances more water-soluble and allow for their elimination from the body. 5
1. Yuan F et al. Anti-estrogenic activities of indole-3- carbinol in cervical cells: implication for prevention of cervical cancer. Anticancer Res. 1999 May Jun;19(3A):1673-80.
2. Frydoonfar HR, McGrath DR, Spigelman AD. The effect of indole-3-carbinol and sulforaphane on a prostate cancer cell line. ANZ J Surg. 2003 Mar;73(3):154-6.
3. Chinni SR, Li Y, Upadhyay S, Koppolu PK, Sarkar FH. Indole3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells. Oncogene. 2001 24;20(23) :29236.
4. Zhang J et al. Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells. Cancer. 2003 Dec.
5. Zółtaszek R, Hanausek M, Kiliańska ZM, Walaszek Z. Biologiczna rola kwasu D-glukarowego i jego pochodnych; potencjalne zastosowanie w medycynie [The biological role of D-glucaric acid and its derivatives: potential use in medicine]. Postepy Hig Med Dosw (Online). 2008 Sep 5;62:451-62. Polish. PMID: 18772850.