Neuro Calm Magnesium is designed for optimal magnesium absorption and bioavailability. With multiple forms of magnesium salts including malate, glycerinate, and L-threonate. Magnesium L-threonate is the only form of magnesium proven in animal studies to cross the blood-brain barrier1. Improving magnesium status of the nervous system supports healthy cognition and memory2-3, learning2-3, sleep4, and managing stress5. **
1 Shen, Y., Dai, L., Tian, H., Xu, R., Li, F., Li, Z., Zhou, J., Wang, L., Dong, J., Sun, L. Treatment of magnesium-L-threonate elevates the magnesium level in the cerebrospinal fluid and attenuates motor deficits and dopamine neuron loss in a mouse model of Parkinson's disease. Neuropsychiatr Dis Treat. 2019 Nov 11;15. 3143-3153. PMID: 31806980.
2 Li, W., Yu, J., Liu, Y. Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model. Mol Brain. 2014 Sep 13;7(1): 65. PMID: 25213836.
3 Slutsky, I., Abumaria, N., Wu, L.J. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010 Jan 28;65(2): 165-177. PMID: 20152124.
4 Pochwat, B., Szewczyk, B., Sowa-Kucma, M. Antidepressant-like activity of magnesium in the chronic mild stress model in rats: alterations in the NMDA receptor subunits. Int J Neuropsychopharmacol. 2014 Mar;17(3): 393-405. PMID: 24067405.
5 Held, K., Antonijevic, I.A., Künzel, H. Oral Mg(2+) supplementation reverses agerelated neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry. 2002 Jul;35(4): 135-143. PMID: 12163983.
** These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.